Publications

For a complete list of our laboratory's publications, click here.

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2024

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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency.

Tesla R, Guhl C, Werthmann GC, Dixon D, Cenik B, Addepalli Y, Liang J, Fass DM, Rosenthal Z, Haggarty SJ, Williams NS, Posner BA, Ready JM, Herz J. Nat Commun. 2024 Jul 20;15(1):6125. doi: 10.1038/s41467-024-50076-8. PMID: 39033178

 

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing.

Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, … See abstract for full author list ➔ medRxiv [Preprint]. 2024 Jun 25:2024.06.24.24309088. doi: 10.1101/2024.06.24.24309088. PMID: 38978643

 

Dissecting OGT's TPR domain to identify determinants of cellular function.

Potter SC, Gibbs BE, Hammel FA, Joiner CM, Paulo JA, Janetzko J, Levine ZG, Fei GQ, Haggarty SJ, Walker S. Proc Natl Acad Sci  U S A. 2024 May 28;121(22):e2401729121. doi: 10.1073/pnas.2401729121. Epub 2024 May 20. PMID: 38768345

 

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.

Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ. Sci Rep. 2024 Apr 20;14(1):9064. doi: 10.1038/s41598-024-59110-7. PMID: 38643236

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2023

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Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy.

Lam M, Kuo SY, Reis S, Gestwicki JE, Silva MC, Haggarty SJ. bioRxiv [Preprint]. 2023 Dec 12:2023.12.11.571147. doi: 10.1101/2023.12.11.571147. PMID: 38168389

 

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing.

Nguyen LD, Wei Z, Silva MC, Barberán-Soler S, Zhang J, Rabinovsky R, Muratore CR, Stricker JMS, Hortman C, Young-Pearse TL, Haggarty SJ, Krichevsky AM. Nat Commun. 2023 Nov 21;14(1):7575. doi: 10.1038/s41467-023-43293-0. PMID: 37989753

 

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations.

Bertucci T, Bowles KR, Lotz S, Qi L, Stevens K, Goderie SK, Borden S, Oja LM, Lane K, Lotz R, Lotz H, Chowdhury R, Joy S, Arduini BL, Butler DC, Miller M, Baron H, Sandhof CA, Silva MC, Haggarty SJ, Karch CM, Geschwind DH, Goate AM, Temple S. bioRxiv [Preprint]. 2023 Jul 11:2023.07.11.548571. doi: 10.1101/2023.07.11.548571. PMID: 37503195

 

Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation.

Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J. Mol Psychiatry. 2023 Dec;28(12):5237-5250. doi: 10.1038/s41380-023-02152-6. Epub 2023 Jul 4. PMID: 37402854

 

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.

Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. PMID: 37043557

 

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.

Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217864120. doi: 10.1073/pnas.2217864120. Epub 2023 Apr 12. PMID: 37043533

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2022

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Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.

Kumar A, Aglyamova G, Yim YY, Bailey AO, Lynch HM, Powell RT, Nguyen ND, Rosenthal Z, Zhao WN, Li Y, Chen J, Fan S, Lee H, Russell WK, Stephan C, Robison AJ, Haggarty SJ, Nestler EJ, Zhou J, Machius M, Rudenko G. Nucleic Acids Res. 2022 Sep 9;50(16):9548-9567. doi: 10.1093/nar/gkac710. PMID: 36039764

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Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine.

Silva MC, Nandi G, Haggarty SJ. Methods Mol Biol. 2022;2429:143-174. doi: 10.1007/978-1-0716-1979-7_10.PMID: 35507160

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Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.

Fass DM, Lewis MC, Ahmad R, Szucs MJ, Zhang Q, Fleishman M, Wang D, Kim MJ, Biag J, Carr SA, Scolnick EM, Premont RT, Haggarty SJ. Mol Psychiatry. 2022 May 3. doi: 10.1038/s41380-022-01557-z. Online ahead of print.PMID: 35505090

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Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of Tauopathy.

Silva MC, Nandi G, Donovan KA, Cai Q, Berry BC, Nowak RP, Fischer ES, Gray NS, Ferguson FM, Haggarty SJ. Front Cell Neurosci. 2022 Mar 3;16:801179. doi: 10.3389/fncel.2022.801179. eCollection 2022.PMID: 35317195 

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A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.

Hafez AK, Zimmerman AJ, Papageorgiou G, Chandrasekaran J, Amoah SK, Lin R, Lozano E, Pierotti C, Dell'Orco M, Hartley BJ, Alural B, Lalonde J, Esposito JM, Berretta S, Squassina A, Chillotti C, Voloudakis G, Shao Z, Fullard JF, Brennand KJ, Turecki G, Roussos P, Perlis RH, Haggarty SJ, Perrone-Bizzozero N, Brigman JL, Mellios N. Cell Rep. 2022 Jan 18;38(3):110282. doi: 10.1016/j.celrep.2021.110282.PMID: 35045295 

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2021

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Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation.

Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, Mazitschek R, Haggarty SJ, Chatila TA, Karp JM, Zanoni I. iScience. 2021 Oct 11;24(11):103256. doi: 10.1016/j.isci.2021.103256. eCollection 2021 Nov 19.PMID: 34761180 

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Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis.

Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, Spires-Jones TL, Bilbo SD, Vakili K, Cudkowicz ME, Berry JD, DiFiglia M, Silva MC, Haggarty SJ, Sadri-Vakili G. Mol Neurobiol. 2022 Jan;59(1):683-702. doi: 10.1007/s12035-021-02557-w. Epub 2021 Nov 10.PMID: 34757590

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Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins.

Bai P, Lan Y, Patnaik D, Wang H, Liu Y, Chen Z, Yuan G, Afshar S, Striar R, Zagaroli JS, Tocci DR, Langan AG, Haggarty SJ, Wang C.   J Med Chem. 2021 Oct 14;64(19):14745-14756. doi: 10.1021/acs.jmedchem.1c01323. Epub 2021 Sep 22.PMID: 34549949

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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.

Cheng C, Reis SA, Adams ET, Fass DM, Angus SP, Stuhlmiller TJ, Richardson J, Olafson H, Wang ET, Patnaik D, Beauchamp RL, Feldman DA, Silva MC, Sur M, Johnson GL, Ramesh V, Miller BL, Temple S, Kosik KS, Dickerson BC, Haggarty SJ. Sci Rep. 2021 Aug 23;11(1):17029. doi: 10.1038/s41598-021-96227-5.PMID: 34426604 

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ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.

Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S. Cell. 2021 Aug 19;184(17):4547-4563.e17. doi: 10.1016/j.cell.2021.07.003. Epub 2021 Jul 26.PMID: 34314701

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Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.

Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW; Synodos for NF2 Consortium. PLoS One. 2021 Jul 15;16(7):e0252048. doi: 10.1371/journal.pone.0252048. eCollection 2021.PMID: 34264955 

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Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.

Walczyk-Mooradally A, Holborn J, Singh K, Tyler M, Patnaik D, Wesseling H, Brandon NJ, Steen J, Graether SP, Haggarty SJ, Lalonde J. J Neurochem. 2021 Sep;158(5):1058-1073. doi: 10.1111/jnc.15440. Epub 2021 Jun 22.PMID: 34077555

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Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration.

Patnaik D, Pao PC, Zhao WN, Silva MC, Hylton NK, Chindavong PS, Pan L, Tsai LH, Haggarty SJ. ACS Chem Neurosci. 2021 Jan 20;12(2):271-284. doi: 10.1021/acschemneuro.0c00308. Epub 2021 Jan 8.PMID: 33417763

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2020

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Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies.

Silva MC, Haggarty SJ. Int J Mol Sci. 2020 Nov 25;21(23):8948. doi: 10.3390/ijms21238948.PMID: 33255694 Free PMC article. 

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Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.

Saundh SL, Patnaik D, Gagné S, Bishop JA, Lipsit S, Amat S, Pujari N, Nambisan AK, Bigsby R, Murphy M, Tsai LH, Haggarty SJ, Leung AK. ACS Chem Neurosci. 2020 Dec 16;11(24):4128-4138. doi: 10.1021/acschemneuro.0c00380. Epub 2020 Nov 30.PMID: 33253521

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Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease.

Weninger S, Sperling B, Alexander R, Ivarsson M, Menzies FM, Powchik P, Weber CJ, Altar CA, Crystal RG, Haggarty SJ, Loring J, Bain LJ, Carrillo MC. Alzheimers Dement (N Y). 2020 Oct 12;6(1):e12090. doi: 10.1002/trc2.12090. eCollection 2020.PMID: 33083513 

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Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice.

Kovalenko M, Erdin S, Andrew MA, St Claire J, Shaughnessey M, Hubert L, Neto JL, Stortchevoi A, Fass DM, Mouro Pinto R, Haggarty SJ, Wilson JH, Talkowski ME, Wheeler VC. Elife. 2020 Sep 29;9:e55911. doi: 10.7554/eLife.55911.PMID: 32990597 

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Advances toward precision medicine for bipolar disorder: mechanisms & molecules.

Haggarty SJ, Karmacharya R, Perlis RH. Mol Psychiatry. 2021 Jan;26(1):168-185. doi: 10.1038/s41380-020-0831-4. Epub 2020 Jul 7.PMID: 32636474 

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Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons.

Silva MC, Nandi GA, Tentarelli S, Gurrell IK, Jamier T, Lucente D, Dickerson BC, Brown DG, Brandon NJ, Haggarty SJ. Nat Commun. 2020 Jun 26;11(1):3258. doi: 10.1038/s41467-020-16984-1.PMID: 32591533

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HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.

Pao PC, Patnaik D, Watson LA, Gao F, Pan L, Wang J, Adaikkan C, Penney J, Cam HP, Huang WC, Pantano L, Lee A, Nott A, Phan TX, Gjoneska E, Elmsaouri S, Haggarty SJ, Tsai LH. Nat Commun. 2020 May 18;11(1):2484. doi: 10.1038/s41467-020-16361-y.PMID: 32424276

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Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins.

Bai P, Lu X, Lan Y, Chen Z, Patnaik D, Fiedler S, Striar R, Haggarty SJ, Wang C. Nucl Med Biol. 2020 May-Jun;84-85:96-101. doi: 10.1016/j.nucmedbio.2020.04.003. Epub 2020 Apr 9.PMID: 32320910

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Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.

Zhao WN, Tobe BTD, Udeshi ND, Xuan LL, Pernia CD, Zolg DP, Roberts AJ, Mani D, Blumenthal SR, Kurtser I, Patnaik D, Gaisina I, Bishop J, Sheridan SD, Lalonde J, Carr SA, Snyder EY, Haggarty SJ. Transl Psychiatry. 2020 Feb 24;10(1):76. doi: 10.1038/s41398-020-0753-6.PMID: 32094324 

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A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.

Zimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell'Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, Perrone-Bizzozero N, Brigman JL, Mellios N. Mol Psychiatry. 2020 Nov;25(11):2712-2727. doi: 10.1038/s41380-020-0653-4. Epub 2020 Jan 27.PMID: 31988434 

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TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.

Martin P, Wagh V, Reis SA, Erdin S, Beauchamp RL, Shaikh G, Talkowski M, Thiele E, Sheridan SD, Haggarty SJ, Ramesh V. Mol Autism. 2020 Jan 6;11(1):2. doi: 10.1186/s13229-019-0311-3. eCollection 2020.PMID: 31921404 

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Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate.

Zaldivar-Diez J, Li L, Garcia AM, Zhao WN, Medina-Menendez C, Haggarty SJ, Gil C, Morales AV, Martinez A. J Med Chem. 2020 Mar 12;63(5):2638-2655. doi: 10.1021/acs.jmedchem.9b01752. Epub 2019 Dec 26.PMID: 31825616

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2019

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Response to: X-linked miR-506 family miRNAs promote FMRP expression in mouse spermatogonia.

Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF. EMBO Rep. 2020 Jan 7;21(1):e49354. doi: 10.15252/embr.201949354. Epub 2019 Dec 6.PMID: 31808609 

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An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration.

Petcherski A, Chandrachud U, Butz ES, Klein MC, Zhao WN, Reis SA, Haggarty SJ, Ruonala MO, Cotman SL. Cells. 2019 Nov 27;8(12):1531. doi: 10.3390/cells8121531.PMID: 31783699 

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A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.

Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S; Tau Consortium Stem Cell Group. Stem Cell Reports. 2019 Nov 12;13(5):939-955. doi: 10.1016/j.stemcr.2019.09.006. Epub 2019 Oct 17.PMID: 31631020 

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Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.

Bai P, Wey HY, Patnaik D, Lu X, Lan Y, Rokka J, Stephanie F, Haggarty SJ, Wang C.Chem Commun (Camb). 2019 Oct 24;55(86):12932-12935. doi: 10.1039/c9cc06734e.PMID: 31599282

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Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.

Bernard-Gauthier V, Mossine AV, Knight A, Patnaik D, Zhao WN, Cheng C, Krishnan HS, Xuan LL, Chindavong PS, Reis SA, Chen JM, Shao X, Stauff J, Arteaga J, Sherman P, Salem N, Bonsall D, Amaral B, Varlow C, Wells L, Martarello L, Patel S, Liang SH, Kurumbail RG, Haggarty SJ, Scott PJH, Vasdev N. J Med Chem. 2019 Nov 14;62(21):9600-9617. doi: 10.1021/acs.jmedchem.9b01030. Epub 2019 Oct 21.PMID: 31535859

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Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.

Moreno-Yruela C, Fass DM, Cheng C, Herz J, Olsen CA, Haggarty SJ. ACS Chem Neurosci. 2019 Aug 21;10(8):3769-3777. doi: 10.1021/acschemneuro.9b00281. Epub 2019 Aug 5.PMID: 31330099

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Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).

Zhao WN, Hylton NK, Wang J, Chindavong PS, Alural B, Kurtser I, Subramanian A, Mazitschek R, Perlis RH, Haggarty SJ. Mol Cell Neurosci. 2019 Sep;99:103386. doi: 10.1016/j.mcn.2019.06.006. Epub 2019 Jun 14.PMID: 31202891

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Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase.

Read J, Collie IT, Nguyen-McCarty M, Lucaj C, Robinson J, Conway L, Mukherjee J, McCall E, Donohoe G, Flavell E, Peciak K, Warwicker J, Dix C, Van den Hoven BG, Madin A, Brown DG, Moss S, Haggarty SJ, Brandon NJ, Bürli RW. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1962-1967. doi: 10.1016/j.bmcl.2019.05.032. Epub 2019 May 18.PMID: 31153805

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Drug discovery for psychiatric disorders using high-content single-cell screening of signaling network responses ex vivo.

Lago SG, Tomasik J, van Rees GF, Steeb H, Cox DA, Rustogi N, Ramsey JM, Bishop JA, Petryshen T, Haggarty SJ, Vázquez-Bourgon J, Papiol S, Suarez-Pinilla P, Crespo-Facorro B, van Beveren NJ, Bahn S. Sci Adv. 2019 May 8;5(5):eaau9093. doi: 10.1126/sciadv.aau9093. eCollection 2019 May.PMID: 31086815

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Deep Learning Benchmarks on L1000 Gene Expression Data.

McDermott MBA, Wang J, Zhao WN, Sheridan SD, Szolovits P, Kohane I, Haggarty SJ, Perlis RH. IEEE/ACM Trans Comput Biol Bioinform. 2020 Nov-Dec;17(6):1846-1857. doi: 10.1109/TCBB.2019.2910061. Epub 2020 Dec 8.PMID: 30990190 Free

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A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS. Sci Transl Med. 2019 Mar 27;11(485):eaat3005. doi: 10.1126/scitranslmed.aat3005.PMID: 30918111

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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.

Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Elife. 2019 Mar 25;8:e45457. doi: 10.7554/eLife.45457.PMID: 30907729

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Human pluripotent stem cell-derived models and drug screening in CNS precision medicine.

Silva MC, Haggarty SJ. Ann N Y Acad Sci. 2020 Jul;1471(1):18-56. doi: 10.1111/nyas.14012. Epub 2019 Mar 15.PMID: 30875083

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A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1.

Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF. EMBO Rep. 2019 Feb;20(2):e46566. doi: 10.15252/embr.201846566. Epub 2018 Dec 20.PMID: 30573526

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PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.

Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. J Clin Invest. 2019 Jan 2;129(1):364-372. doi: 10.1172/JCI123743. Epub 2018 Dec 10.PMID: 30530989

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Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ; International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH. Nat Med. 2019 Jan;25(1):152-164. doi: 10.1038/s41591-018-0223-3. Epub 2018 Dec 3.PMID: 30510257

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